19 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Diagnosis Algorithm Signs ... Hemolysis: • Autoimmune ... • Extrinsic RBC ... • Intrinsic RBC ... Diagnosis #Algorithm #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... ↑ LDH • Anti-RBC ... Warm #Antibody #Autoimmune ... #diagnosis #management ... #treatment #rheumatology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... progress to MDS or acute ... #diagnosis #management ... #treatment #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
transform into a RBC ... Index > 3: • Acute ... • Hemolysis: Autoimmune ... , Intrinsic RBC ... Production #Index #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... cytopenias (usually anemia ... transformation to acute ... #treatment #hematology ... #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
5) Symptoms of anemia ... marrow failure with anemia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Cold AIHA • Alloimmune ... elliptocytosis - RBC ... immune-complex hemolytic anemia ... • Acute HTR ... Algorithm #Causes #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... • Rare: DAH, acute ... , Anaphylaxis, Acute ... APML #diagnosis #management ... #hematology #oncology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - ACS, AKI, acute ... >100k, + lab signs ... TLS #diagnosis #management ... #hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Corticosteroid use • Autoimmune ... 21% had normal WBC ... #CBC #hematology ... #pathophysiology