29 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome in APML ... Triggers: ATRA treatment ... Pathophysiology ... fluid overload, PCC ... #hematology #oncology
Hantavirus
Pathogen: Hantavirus - Rodents are the primary reservoir
Transmission:
 • Shed in the urine, feces, saliva of
cellars, barns and ... +/- diarrhea Diagnosis ... Treatment: • ... #management #treatment ... #microbiology #
Septic Arthritis: Pathogenesis and clinical findings
Notes:
- Septic Arthritis is typically monoarticular & the knee is involved
monoarticular & the knee ... a +ve culture Microbiology ... S.A. can also be caused ... SepticArthritis #pathophysiology ... #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
and Management ... old, ~10,000 new cases ... only curative treatment ... #Management #treatment ... #hematology #oncology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Scl70 (in some cases ... -70 (in some cases ... conditions - Sp-100, PML ... #differential #diagnosis ... #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... : Blast crises ... smear: Blasts APML ... #Leukemia #Hematology ... #Oncology #Diagnosis
Visceral Leishmaniasis - Diagnosis and Management Summary
Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi
Where: South Asia, East
Weight Loss • Can cause ... histopathology, culture, PCR ... , K39) Treatment ... #management #treatment ... infectiousdiseases #microbiology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
- Differential Diagnosis ... pathogens, including PML ... Antimicrobial treatment ... Hydrocephalus possible PML ... Demyelinating disease caused
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... is similar to PML ... well-defined than PML ... Diagnosis: MRI ... PML (JC virus)
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
without other cause ... : 33% • Treatment ... : No • Treatment ... Transfusion #Reactions #hematology ... #diagnosis #comparison