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differential management table oncology activetb aflp anemia cold hellp hemolytic latenttb obstetrics pregnancy rheumatology tb thrombocytopenia tuberculosis activation acute agglutinin
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Cold Autoimmune Hemolytic ... Spherocytes • Treatment ... • Treatment: Warm ... #Anemia #hematology ... #diagnosis #comparison
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
defects. 1) HELLP (Hemolysis ... Elevated Liver tests ... AFLP #obstetrics #hematology ... #diagnosis #table ... #comparison
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... defects. 1) HELLP (Hemolysis ... Elevated Liver tests ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Drug-associated, PCH ... , Evans Syndrome ... Laboratory Tests ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... Test: Donath-Landsteiner ... test #cold # ... #anemia #hematology
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
Diagnostic Criteria ... for Sweet Syndrome ... Excellent response to treatment ... count >10 x 10^3/pL ... #Hematology #Dermatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Renal Failure Treatment ... fluid overload, PCC ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... • Bicytopenia Treatment ... • Infection should ... #management #treatment ... #hematology
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