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management lupus table differential erythematosus syndrome systemic thrombocytopenia ana antibody antinuclear causes coagulation cytoplasmic patterns summary testing anemia antibodies apml
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Warm vs Cold Autoimmune ... Spherocytes • Treatment ... transient hemolysis • Treatment ... Hemolytic #Anemia #hematology ... #diagnosis #comparison
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
, autoimmune hepatitis ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... Associations #diseases #diagnosis ... #table #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SLE ... pattern: - SjS, SLE ... body-like: - Neurologic ... #differential #diagnosis ... #rheumatology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Viral hepatitis, Autoimmune ... - Malignancy, Autoimmune ... RA, SLE), Post-partum ... Summary #table #comparison ... #diagnosis #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... Erythematosus #SLE ... #CNS #neurology ... #rheumatology #
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Can also see mechanics ... after 2 years of treatment ... #Myositis #diagnosis ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Cytopenia +++ (Plt ... solid cancers • Autoimmune ... diseases: SLE++ ... #summary #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
AMA Speckled: • SLE ... body-like: • Neurologic ... conditions, SjS, SLE ... #differential #diagnosis ... #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
least 2 joints • Neurologic ... pericarditis • Hematologic ... Thrombocytopenia, Autoimmune ... Erythematosus #diagnosis ... #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... #Differential #Diagnosis ... Causes #Workup #hematology
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