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diagnosis lupus hematology neurology syndrome erythematosus systemic causes antibody classification oncology summary algorithm ana antinuclear druginduced nephritis patterns testing thrombocytopenia
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SLE ... pattern: - SjS, SLE ... Speckled: - SLE ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... life-threatening • Treatment ... Usual therapeutic management ... Erythematosus #Diagnosis #Management ... #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management ... #treatment
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
• Specific for SLE ... severe disease Treatment ... Erythematosus #SLE ... Summary #diagnosis #rheumatology ... #management
Lupus Nephritis Primer Class I - Minimal Mesangial Class II - Mesangial Proliferative Class Ill - Focal Proliferative Class IV
Lupus #Nephritis #SLE ... Classification #Classes #differential ... #diagnosis #management ... #nephrology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
AMA Speckled: • SLE ... conditions, SjS, SLE ... Golgi/polar: • SLE ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Hematuria in Post-Renal Transplant Patient Prevalence up to 12% in the postrenal transplant patient • Bacterial: Escherichia
Goodpasture's syndrome, SLE ... Renal #Transplant #differential ... #blood #urine #management ... #treatment #nephrology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... life-threatening • Treatment ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
• Light chain (LC ... nephropathy • LC ... malignancies Treatment ... Cancer #Oncology #Differential ... Classification #Nephrology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
• Blood smear: Differential ... Anemia #diagnosis #management ... #treatment #rheumatology
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