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diagnosis lupus erythematosus ana antinuclear syndrome antibody hematology classification disease summary testing antibodies autoimmune cytoplasmic druginduced neurology nuclear signs symptoms
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
: - SLE, SSc ... : - SjS, SLE, ... Speckled: - SLE ... #differential # ... diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... Antibodies #ANA #patterns ... #rheumatology # ... diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus (SLE ... erythematosus (SLE ... erythematosus (SLE ... #rheumatology # ... diagnosis #differential
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... /systemic sclerosis ... severe disease Treatment ... Summary #diagnosis #rheumatology ... #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management ... life-threatening • Treatment ... #lupus #Systemic ... #Summary #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Testing Cytoplasmic Patterns ... AMA Speckled: • SLE ... #Cytoplasmic #Patterns ... #differential # ... diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
: • SLE, SSc, ... : • SjS, SLE, DM ... : • SSc, PBC/SSc ... #differential # ... diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Erythematosus (SLE ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management ... #treatment
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome - Treatment ... Ulcers: • Treatment ... Neuro disease: • Systemic ... #management #pharmacology ... #rheumatology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
• Blood smear: Differential ... FOR a cause → Systematic ... Anemia #diagnosis #management ... #treatment #rheumatology
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