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diagnosis differential management algorithm thrombosis acid acidosis antiphospholipid aplastic apls classification clots dermatology elevation embolism encephalopathy hepatic hypercoagulable hyperkalemia k
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... APLS:PLT ↓ HEMATOLOGIC ... neoplasms - PNH ... Diagnosis #clots #hematology
Tranexamic Acid - Indications and Pharmacology Pharmacokinetics: • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Tranexamic Acid - Indications ... and Pharmacology ... Potentially increases venous ... & arterial thrombotic ... hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Venous Thrombosis ... Diagnosis Framework VENOUS ... coagulation and other causes ... Thrombosis #Embolism #Venous ... #hematology #differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... • Reaction to Medications ... Diagnosis #Algorithm #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... deficiencies - PNH ... gangrenosum • Bacterial ... Differential #Diagnosis #hematology ... #rheumatology #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... and petechiae Causes ... - Antithyroid medications ... Treatment: ... #oncology #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
perfusion - shock->treatments ... before beginning treatment ... Acute pulmonary edema ... ’s • Reduced Arterial ... 30mmHg) - Severe anemia
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
S/Sx: Most pts ... Weakness, cramping, nausea ... - ↓ Effective arterial ... only if no clear cause ... caution in HTN & edema
Hepatic Encephalopathy Treatment • Lactulose: - Oral liquid, 30-45mL 2-4x/day, titrated to 2-4
Encephalopathy Treatment ... swallow) - Via enema ... For refractory cases ... Encephalopathy #Treatment ... #management #hepatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Workup Algorithm INDICATIONS ... clinical episodes of arterial ... , venous, or small-vessel ... maternal chromosomal causes ... Algorithm #diagnosis #hematology
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