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lupus hematology syndrome erythematosus systemic cardiology disease druginduced summary table algorithm differential medications oncology thrombocytopenia activation adultonset aecopd apml aspirin
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Management Summary ... life-threatening • Treatment ... Erythematosus #Diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
• Specific for SLE ... severe disease Treatment ... #Summary #diagnosis ... #rheumatology # ... management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... permeability Diagnosis ... Erythematosus #SLE ... CNS #neurology #rheumatology ... #management #treatment
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... life-threatening • Treatment ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... hepatitis • Pulmonary ... Stills #Disease #diagnosis ... #management #treatment ... #rheumatology
Salicylate Toxicity - Diagnosis and Management Consider if: 1) Patient is hot and altered 2) You see tachypnea with
Salicylate Toxicity - Diagnosis ... altered 2) You see ... , Diaphoresis, Pulmonary ... Toxicity #Toxicology #diagnosis ... #management #Treatment
Algorithm for Management of Acute Exacerbation of COPD (AECOPD) Obtain workup for alternate diagnoses and relevant comorbidities:
Algorithm for Management ... for alternate diagnoses ... Lung US, Echo, LE ... #Exacerbation #treatment ... #pulmonary
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT/PTT ... + Bleeding Treatment ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Autoimmune diseases: SLE ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... opacities • Diagnosis ... Renal Failure Treatment ... #management #hematology
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