21 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Differential Diagnosis Algorithm ... Abnormal peripheral smear ... : • Autoimmune ... • Extrinsic RBC ... • Intrinsic RBC
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... AIHA • Anemia: macrocytic ... ↑ LDH • Anti-RBC ... C3d • Blood smear ... diagnosis #management #treatment
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Differential Diagnosis Algorithm ... Peripheral blood smear ... Hypochromic & microcytic ... RBCs, DAT (-) → ... idiopathic, malignancy, autoimmune
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... -100): • Non-hemolytic ... Spherocytosis, G6PD, PK, HbC ... - Extrinsic: Autoimmune ... Infections Macrocytic
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic Algorithm ... 95 (or 100) is macrocytic ... acute blood loss, hemolysis ... Algorithm by Dr. ... #Macrocytic
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Differential Diagnosis Algorithm ... Polychromatic Macrocytes ... Bleed • Hemolysis ... Polychromatic Macrocytes ... Microangiopathic Hemolytic
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia (sometimes) Macrocytic ... spherocytosis, Autoimmune ... hemolytic anemia ... Agglutinate: Cold autoimmune ... hemolytic anemia
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... Membrane): - Autoimmune ... Peripheral Blood Smear ... Urobilinogen #Hemolysis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Differential Diagnosis Algorithm ... Normal Blood Smear ... • Drugs Oval Macrocytes ... Neutrophils - Low RBC ... Pernicious Anemia RBCs
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... Differential Diagnosis Algorithm ... Cold AIHA • Alloimmune ... elliptocytosis - RBC ... Differential #Diagnosis #Algorithm