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diagnosis rheumatology management differential erythematosus sle systemic antibody patterns cytoplasmic disease druginduced neurology nuclear syndrome table workup arthritis cerebritis cns
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... searched for when ANA ... Raynaud's phenomenon ... #autoantibodies
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... (ANA) - 95% - Initial ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... severe disease Treatment
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... ARUPConsult @ARUPLabs #ANA ... #Testing #Nuclear
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Photosensitivity 29% - Raynaud's ... Auto-Antibodies: - ANA ... Differential Diagnosis and ... Erythematosus #Diagnosis #autoantibodies
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... the formation of autoantibodies ... Diagnosis of Lupus ... Puncture, EEG Treatment ... diagnosis #management #treatment
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... constitutional symptoms • Treatment ... of autoantibodies ... Workup: - ANA ... life-threatening • Treatment
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
with response to treatment ... serum lgE, no autoantibodies ... (antinuclear antibodies ... IgG4+ cells" Treatment ... phenotypes #workup #treatment
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Testing Cytoplasmic ... CTD-ILD, IIM, Raynaud ... #Antinuclear #Antibody ... #Testing #Cytoplasmic
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... #Antinuclear #Antibody ... #Testing #Nuclear
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... erythematosus (SLE) - Antinuclear ... - CCP antibody testing ... C serology testing ... workup #diagnosis #testing
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