41 results
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... severe disease Treatment ... #Systemic #Lupus
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Homogeneous: Systemic lupus ... , Drug-induced Lupus ... Speckled: Systemic lupus ... Kumfer @AnnKumfer #Antinuclear ... rheumatology #diagnosis #differential
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Farr assay) and lupus ... with MCTD and Raynaud's ... Lupusreference #Antinuclear
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... #Antibody #Testing ... Cytoplasmic #Patterns #differential
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Photosensitivity 29% - Raynaud's ... (aPL) 30-45% Differential ... Diagnosis and Lupus ... symptoms #mimickers #differential
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... , Drug-induced Lupus ... , Drug-Induced Lupus ... Kumfer @AnnKumfer #Antinuclear ... rheumatology #diagnosis #differential
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Antinuclear Antibody ... Testing Cytoplasmic ... CTD-ILD, IIM, Raynaud ... #Antibody #Testing ... Cytoplasmic #Patterns #differential
Great Mimickers - SHALLOTS Mnemonic

S- Syphilis - Neurosyphilis, aortitis, gummas... Granulomas can form anywhere! Skin, mucosa,
anything L - Lupus ... arthritis, alopecia, Raynaud ... Could be lupus in ... Mnemonic #Diagnosis #Differential
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... distinction has HUGE treatment ... and first-line treatment ... awaiting confirmatory testing
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... #Antibody #Testing ... Nuclear #Patterns #differential