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diagnosis systemic symptoms differential erythematosus lupus ana sle testing antibody patterns autoantibodies cytoplasmic management nuclear scleroderma sclerosis workup arthritis autoimmune
Systemic Sclerosis (Scleroderma) Limited - CREST: • Calcinosis • Raynaud phenomenon • Esophageal dysmotility • Sclerodactyly •
Calcinosis • Raynaud ... Scleroderma #diagnosis #signs ... #symptoms #rheumatology
Cutaneous and Systemic Findings in Dermatomyositis Cutaneous Findings: - Heliotrope sign and edema - Nail-fold changes -
- Heliotrope sign ... or shawl sign ... - Gottron's sign ... Gottron's papules - Raynaud's ... Dermatomyositis #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
defect (rare) Raynaud's ... Leucopenia/lymphopenia, Thrombocytopenia ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... SSc, PM/SSc OS, Raynaud ... CTD-ILD, IIM, Raynaud ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... Summary #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Photosensitivity 29% - Raynaud's ... Neurological 12% - Thrombocytopenia ... autoantibodies #signs ... #differential #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... with MCTD and Raynaud's ... Lupusreference #Antinuclear ... erythematosus #diagnosis #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
skin thickening Signs ... • Vascular: Raynaud's ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... CTD-ILD, IIM, Raynaud ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... Lupus enteritis, Raynaud's ... Erythematosus #SLE #Signs ... Symptoms #diagnosis #rheumatology
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