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diagnosis differential management sle erythematosus systemic ana antinuclear hematology patterns table algorithm criteria cytoplasmic disease druginduced laboratory neurology nuclear summary
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
- Anti-dsDNA antibody ... the presence of antibody ... nuclear antigen - Antiphospholipid ... antibody positivity ... #Diagnosis #Rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Immunologic domains: • Antiphospholipid ... antibody domain ... domain: Anti-dsDNA antibody ... , Anti-Sm antibody ... Erythematosus #diagnosis #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... (anti-nuclear antibody ... antibodies) • Antiphospholipid ... Antibody Syndrome
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid ... Hypercoagulable Workup ... : • Lupus Anticoagulant ... ARUPLabs #APLS #Antiphospholipid ... Hypercoagulable #Workup
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
reticularis • Antiphospholipid-antibody ... lesions • Discoid lupus ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... severe disease Treatment ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
diagnosis and treatment ... encephalomyelitis • MOG antibody-associated ... demyelination • Antiphospholipid ... syndrome • Systemic lupus
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... #Testing #Nuclear ... differential #diagnosis #rheumatology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
INDICATIONS FOR TESTING ... evaluation or workup ... 1,500 cells/µL Workup ... glucocorticoid treatment ... Differential #diagnosis #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... • Immunologic Workup ... life-threatening • Treatment ... Management #Summary #rheumatology
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