12 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ... ANA (anti-nuclear ... Polymerase Ill • ANCA ... perinuclear), C-ANCA ... (cytoplasmic)
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Antibody) and ANCA ... Antineutrophil cytoplasmic ... ) • Systemic lupus ... in drug-induced SLE ... antibodies #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... Testing - Nuclear ... and Cytoplasmic ... ARUPConsult @ARUPLabs #ANA ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
and Management ... • Immunologic Workup ... : - ANA > ... life-threatening • Treatment ... #Summary #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Testing Cytoplasmic ... CTD-ILD, IIM, Raynaud ... ARUPConsult @ARUPLabs #ANA ... #Testing #Cytoplasmic ... differential #diagnosis #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... : - ANA > ... • Immunologic Workup ... : - ANA > ... #table #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Antinuclear (ANA ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... severe disease Treatment ... Summary #diagnosis #rheumatology ... #management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... , a negative ANA ... ACE level, CXR, ANCA ... multiple myeloma) • ANA
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... ARUPConsult @ARUPLabs #ANA ... differential #diagnosis #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... (e.g. systemic lupus ... erythematosus (SLE ... classification #rheumatology