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diagnosis differential oncology disease pharmacology causes hepatology hivaids idsa prevention syndrome algorithm lupus sle autoimmune erythematosus hemophagocytic hlh infectiousdiseases lymphohistiocytosis
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Reactive: • Anemia ... deficiency) • Infection ... Sepsis • Non-infectious ... Myelofibrosis • Chronic ... causes #Platelets #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelofibrosis Infectious ... : • Acute or Chronic ... effect following treatment ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... : Chronic infections ... Diagnosis #Algorithm #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... of Chronic Disease ... Infection) High ... Algorithm #Causes #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... : • Recurrent infections ... Treatment: • Consider ... #diagnosis #management ... #treatment #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
of chronic inflammation ... deficiencies: Chronic ... (e.g. cancer, infection ... G6PD deficiency), Infections ... Production #Index #hematology
Medications for Prevention of Chronic Gout Colchicine (Colcrys) Pegloticase (Krystexxa) Probenecid Xanthine oxidase inhibitors: - Allopurinol (Zyloprim) - Febuxostat (Uloric) #Chronic
Prevention of Chronic ... Febuxostat (Uloric) #Chronic ... #Medications #Treatment ... #Management #AAFP ... #Rheumatology
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 Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... only curative treatment ... #treatment #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... Autoimmune #Hemolytic #Anemia ... #diagnosis #management ... #treatment #rheumatology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute infection ... malignancies • Anemia ... hemorrhage) • Chronic ... Myelofibrosis (MF) • Chronic ... Diagnosis #Causes #hematology
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