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SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
Systemic Lupus Erythematosus ... CUTANEOUS LUPUS - CHRONIC ... NEUROLOGIC - HEMOLYTIC ANEMIA ... (<1000/MM3) - THROMBOCYTOPENIA ... #Diagnosis #Rheumatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... : • Acute or Chronic ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... Reactive: • Anemia ... Non-infectious (malignancy, rheumatologic ... Myelofibrosis • Chronic ... Thrombocytosis #Differential
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Lymphadenopathy - Differential ... Systemic Lupus Erythematosus ... Age > 50 • Chronic ... Algorithm #Causes #Hematology ... #Oncology
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Anemia - Underproduction ... - Anemia of chronic ... of chronic kidney ... Underproduction #Algorithm #hematology ... #diagnosis #differential
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... of Chronic Disease ... Classification #Differential ... Algorithm #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential ... Megakaryopoiesis • Aplastic Anemia ... #Differential # ... Algorithm #Causes #Hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... (aPL) 30-45% Differential ... #rheumatology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Systemic lupus erythematosus ... #Pancytopenia #Differential ... #Diagnosis #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... RA, SLE, PRV, Chronic ... #Differential # ... Algorithm #Causes #Hematology