29 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... SLE), Sjogren's ... Syndrome (SS), Polymyositis ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
and Clinical Findings ... RA) or systemic lupus ... erythematosus ( ... SLE) Signs / Symptoms ... #Diagnosis #Signs
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... activity Anti-Ro ... heart block • Sjogren ... #SLE #Summary #diagnosis ... #rheumatology #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... Differential Diagnosis ... dermatomyositis, Sjogren ... Clinical Features
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... 40% Target: SS-A/Ro ... is clinically suspected ... overlap syndromes ... #erythematosus
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
(SLE): ANA (anti-nuclear ... others (RNP, aPL antibodies ... Anticoagulant (LAC) • Sjogren ... Syndrome: Anti-Ro ... #Rheumatology #diagnosis
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... SLE), Sjogren's ... Syndrome (SS), Polymyositis ... Syndrome, Myositis ... #rheumatology #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... erythematosus ... in drug-induced SLE ... syndrome 1. ... Anti-Ro/SSA
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anti-SSA (Ro), ... Anti-SSB (La) - Sjogren's ... syndrome Anti-TSHR ... Associations #diseases #diagnosis ... #rheumatology #antibodies
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... #Erythematosus ... #Diagnosis #Management