SJS antinuclear syndrome hematology anemia antibodies patterns anca systemic differential sle table

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ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

ANA Patterns and ... ), Sjogren's Syndrome ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... : The ANA patterns ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential

ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

ANA (Antinuclear ... ) • Systemic lupus ... in drug-induced SLE ... cases • Sjögren syndrome ... #rheumatology #

Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
• Homogeneous pattern:
-

Antinuclear Antibody ... : - SjS, SLE, ... #Antinuclear #Antibody ... #differential # ... diagnosis #rheumatology

Autoantibodies in Rheumatology
• Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and

• Lupus (SLE): ... others (RNP, aPL antibodies ... LAC) • Sjogren Syndrome ... • Scleroderma (Systemic ... #associations #table

Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern:
• SLE, SSc, AIH, JIA
• dsDNA, chromatin,

Antinuclear Antibody ... : • SLE, SSc, ... : • SjS, SLE, DM ... #differential # ... diagnosis #rheumatology

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... and Systemic lupus ... 30-40% Target: SS-A ... overlap syndromes ... #table #ANA

Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA:
• PBC, SSc, PBC/SSc OS, PBC/SjS OS
• AMA
Speckled:
•

Antinuclear Antibody ... Testing Cytoplasmic Patterns ... ARUPConsult @ARUPLabs #ANA ... #differential # ... diagnosis #rheumatology

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

Vasculitides - Differential ... ) pattern: antibodies ... ) pattern: is usually ... vasculitis, and SLE ... #diagnosis #rheumatology

Systemic Lupus Erythematosus - Diagnosis
Manifestations:
- Arthritis 69%
- Malar rash 40%
- Fever 36%
-

Systemic Lupus Erythematosus ... - Hemolytic anemia ... Auto-Antibodies ... : - ANA 95-100% ... #rheumatology

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