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diagnosis rheumatology differential management erythematosus lupus algorithm causes sle ana dermatology treatment disease secondary table workup antibody associations autoimmune diseases
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
SLE), Sjogren's Syndrome ... (SS), Polymyositis ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... SLE), Sjogren's Syndrome ... (SS), Polymyositis ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... others (RNP, aPL antibodies ... Antiphospholipid Antibody Syndrome ... LAC) • Sjogren Syndrome ... • Scleroderma (Systemic
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... drug-induced SLE) • Systemic ... cases • Sjögren syndrome ... #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... 30-40% Target: SS-A ... SLE-SSc-AlM overlap syndromes ... #autoantibodies
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... LDH • Anti-RBC autoantibodies ... FOR a cause → Systematic ... management #treatment #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... La) - Sjogren's syndrome ... #Autoantibodies ... diagnosis #table #rheumatology ... #antibodies
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Hemolytic anemia ... SLE-Related Auto-Antibodies ... Erythematosus #Diagnosis #autoantibodies ... #differential #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... B12 - Anti-IF Antibodies ... B12 - Anti-IF Antibodies ... Myelodysplastic Syndromes ... Algorithm #Causes #Hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology
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