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ana disease lupus differential patterns treatment erythematosus sle stills systemic adultonset antibody hematology syndrome testing antibodies aosd blood cytoplasmic dermatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
SHARP - Lupus Diagnosis ... D Discoid Rash ... A Antinuclear ... erythematosus #rheumatology ... #diagnosis #mnemonic
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... pattern: - SjS ... ARUPLabs #ANA #Antinuclear ... #differential #diagnosis ... #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Sjogren's Syndrome (SS ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... PBC/SSc OS, PBC/SjS ... ARUPLabs #ANA #Antinuclear ... #differential #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... 30-40% Target: SS-A ... Lupusreference #Antinuclear ... erythematosus #diagnosis ... #rheumatology #
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Speckled pattern: • SjS ... Raynaud phenomenon, SjS ... #differential #diagnosis ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... and Management ... Manifestations: Malar rash ... Erythematosus #Diagnosis ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Sjogren's Syndrome (SS ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology ... #diagnosis #differential
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... Differential Diaqnoses ... Stills #Disease #diagnosis ... #management #treatment ... #rheumatology
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