224 results
diagnosis differential rheumatology causes management sle algorithm erythematosus clinical systemic dermatology signs nephrology symptoms neurology treatment classification syndrome cardiology hematology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... Inclusion Body Myositis ... Anti-retrovirals, Gemcitabine Lupus ... , +Anti-dsDNA, Myositis ... uncommon 5-15% of lupus
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... heliotrope rash, Shaw ... triad of ILD, myositis ... #Autoimmune #Myositis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Normal CK - Myositis ... #Systemic #Lupus
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
periorbital heliotrope, shawl ... Necrotizing Autoimmune Myositis ... Inclusion Body Myositis
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
M DAMN SHARP - Lupus ... Antibody (ANA) M Mucositis ... sle #systemic #lupus
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... anemia 4% - Myositis ... Diagnosis and Lupus ... : Drug-induced lupus ... SLE #Systemic #Lupus
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... glycoprotein I (ß2GP), Lupus ... Peptide (CCP) • Myositis
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
• Transverse myelitis ... positive NMO only): Myositis ... disorders (Systemic lupus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Glomerulonephritis Myositis ... Thrombocytopenia #Lupus
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Homogeneous: Systemic lupus ... , Drug-induced Lupus ... Speckled: Systemic lupus ... Sjögren Syndrome, Myositis ... , Drug-Induced Lupus
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