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differential nephrology pulmonary workup algorithm antibodies arthritis causes classification dermatology renal testing ana antinuclear associations autoantibodies disease glomerular glomerulonephritis management
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
PR3 Anti-GBM disease ... @AnnKumfer #ANCA ... #CANCA #PANCA # ... MPO #PR3 #Diagnosis ... #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Vasculitis: • ... Microscopic polyangiitis ... Renal-limited vasculitis ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
hepatitis Anti-CCP, Rheumatoid ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... #diagnosis #table ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... Vasculitis: + MPO-ANCA ... : Systemic rheumatic ... purpura: strong sign ... #rheumatology #
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis, Microscopic ... polyangiitis) - ANCA-negative ... erythematosus, Rheumatoid ... testing: anti-ANCA
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... Nodosa (PAN), ANCA ... associated vasculitis ... (rare) • Rheumatic ... #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
ribonucleoprotein) • RA: Rheumatoid ... Polymerase Ill • ANCA ... Vasculitis: P-ANCA ... perinuclear), C-ANCA ... #diagnosis #associations
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
small vessels - ANCA-associated ... granulomatosis - microscopic ... #Vessels #Diagnosis ... #Rheumatology # ... Diagnosis
ANCA-Associated Vasculitis There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated ... inflammation: • Microscopic ... StanfordChiefs #ANCA ... #diagnosis #algorithm ... #rheumatology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
- Differential Diagnosis ... glomerulonephritis 90%: - ANCA ... Double Positive (ANCA ... Antiphospholipid Syndrome, Rheumatoid ... #Differential #Diagnosis
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