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differential hematology anemia causes algorithm classification deficiency extravascular intravascular mcv medications rbc allergy antiglobulin atlas autoimmune bloodcell bodies calculation dat
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... atypical HUS) - Drug-induced ... • Mechanical hemolysis ... #hematology #hemolysis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... delayed HTR • Drug-induced ... Intravascular - Hemolysis ... • PNH • Drug-induced
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... Intravascular Hemolysis ... Microangiopathic hemolytic ... purpura (TTP), Hemolytic ... infection) - Drugs
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... in Hemolytic Anemia ... • Hapten (Drug ... #medications #Hemolytic ... table
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Transfusion reactions, Drug-associated ... Membrane Defects, Drugs ... Urobilinogen #Hemolysis ... #hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
in Autoimmune Hemolysis ... DAT Negative Hemolysis ... ), C3d ( + ) Drug-associated ... DAT #Autoimmune #Hemolysis ... #hematology #diagnosis
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Asplenism, Severe hemolytic ... deficiency, Oxidant drugs ... Sideroblastic anemia, Hemolytic ... Inclusions #Bodies #diagnosis ... #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... Orotic aciduria, Drugs ... #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... AIHA: warm, cold, drug ... udaygulati #Hemolytic ... classification #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
suppression (e.g. drugs ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... Production #Index #hematology ... #differential #diagnosis
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