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diagnosis differential hematology anemia algorithm causes hemolytic hemolysis atlas clinical elevated extravascular hereditaryspherocytosis intravascular laboratory morphology nejm rbc antibody autoimmune
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
in Hereditary Spherocytosis ... cause hereditary spherocytosis ... Pathophysiology #Honc #IM #Spherocytosis
Peripheral-Blood Smear. A peripheral-blood smear (Wright’s stain) shows spherocytes (selectively indicated by arrows). #Clinical #Pathology #Spherocytosis
Clinical #Pathology #Spherocytosis
The differential diagnosis for an elevated MCHC (mean corpuscular hemoglobin concentration) includes: Conditions with Abnormal RBCs: •
Abnormal RBC • Spherocytosis
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
schizocytes, Positive → spherocytosis
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
• Congenital Spherocytosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Spherocytosis, G6PD
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
→ Hereditary spherocytosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
• Hereditary spherocytosis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Hereditary spherocytosis
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Spherocytes - Hereditary spherocytosis
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