14 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Causes of Extravascular ... - Differential Diagnosis ... Warm AIHA • Cold ... #Algorithm #Causes ... #Hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... Drugs 5. ... #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Autoimmune: Warm AIHA, Cold ... Membrane Defects, Drugs ... Thalassemias, Unstable ... #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... • AIHA: warm, cold ... , drug induced ... #Differential #Diagnosis ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... (e.g. primary cold ... infection) - Drugs ... #hematology #anemia
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... prolonged, there could ... Drugs: Direct or ... indirect inhibitory drugs ... #hematology #coagulation
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
child * Severe cases ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison ... #Table
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
child * Severe cases ... AFLP #obstetrics #hematology ... #diagnosis #table ... #comparison
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
G6PD deficiency, Unstable ... disorders, Oxidative drugs ... Cell Agglutinate: Cold ... #differential #diagnosis ... #hematology #microscopy
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Discontinuation of causal ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management