37 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup History ... count, family history ... test, ANA (e.g., SLE ... or if a primary hematologic ... #Workup #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... - Anti-histone ... #comparison #table ... #rheumatology # ... diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Positive in 60-80% of cases ... - Anti-histone ... Usual therapeutic management ... #Summary #rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
RA Anti-dsDNA - SLE ... Anti-histone - ... Drug-induced SLE ... diseases #diagnosis #table ... #rheumatology #
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... • Special cases ... #Measurement #SLE ... #rheumatology # ... levels #lupus #management
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... anti-dsDNA Anti-histone ... Association with both SLE ... erythematosus #diagnosis #rheumatology ... #table #ANA
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm
Relative - Normal RBC Mass / Decreased Plasma Volume
Causes of Polycythemia ... Abnormal Abdominal Ultrasound ... positive Family History ... Diagnosis #Algorithm #Causes ... #Hematology
Global Alliance algorithm to improve outcomes in acne.
†With small nodules (>0.5–1 cm).
‡Consider physical removal of comedones.
§Second
Second course in case ... For pregnancy, see ... ††See text. alt. ... #Management #Dermatology
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Diagnosis and Management ... altered 2) You see ... no respiratory cause ... meningitis 5) History ... Level: 150mg/kg Management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... Anti-histone (in ... drug-induced SLE ... seen in 30—70% of cases ... antibodies #diagnosis #rheumatology