44 results
diagnosis signs causes algorithm management hepatology hypercalcemia neurology hematology msk primary syndrome workup alkaline alp gh growthhormone hyperthyroidism oncology phosphatase
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... easily/weakness, Bone ... pain Psychiatric Symptoms ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Osteoporosis: Pathogenesis and risk factors • Age > 30 (post-peak bone mass) • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... liver or kidney disease ... #Osteoporosis #pathophysiology ... #signs #symptoms
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... - Highest • Bone ... Most common symptoms ... - Bone symptoms ... ALP #Elevation #Differential
Paget’s Disease: Pathogenesis and Clinical Findings • Incr serum CTx - marker of bone resorption •
Paget’s Disease: ... CTx - marker of bone ... formation #PagetsDisease ... #pathophysiology ... diagnosis #signs #symptoms
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
due to increased bone ... failure, Addison's disease ... Granulomatous diseases ... Hypercalcemia #Causes #differential ... calcium #high #endocrinology
Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
, Kidney Disease ... - Accelerated Bone ... Formation: Hungy Bone ... Diagnosis #Management #endocrinology ... #differential #
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... etiology Signs/Symptoms ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia - Differential ... Granulomatous Disease ... Miscellaneous - Bone ... Hypercalcemia #Differential ... Algorithm #causes #endocrinology
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease ... Pathophsiology ... Osteonecrosis, bone ... #Gauchers #Disease ... Diagnosis #Signs #Symptoms
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: ... cause excessive bone ... hearing loss #PagetsDisease ... #pathophysiology ... diagnosis #signs #symptoms
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