79 results
Initial treatment of renal bone disease and cinacalcet for secondary hyperparathyroidism
Phosphate binders reduce hyperphosphataemia and hyperparathyroidism.
Initial treatment of renal ... bone disease and ... which reduces bone ... #Pharmacology #Pathophysiology
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... Leukemia) • GI diseases ... liver or kidney disease ... #Osteoporosis #pathophysiology
Hypercalcemia of Malignancy - Pathophysiology
PTH-mediated
 • Parathyroid cancer
 • Ectopic production: Small cell lung cancer, ovarian
of Malignancy - Pathophysiology ... D - Increased renal ... resorption in the bone ... resorption in the bone ... Cell of lung, Renal
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Tumours - See Bone ... Alkaline Phosphatase Renal ... Secondary to Chronic Renal ... • Bone Marrow ... • Renal Disease
Renal Effect of NSAIDs Inhibition of Prostaglandin Synthesis

 - Renal disease, Cardiovascular disease -> Decreased renal
Renal Effect of ... disease, Cardiovascular ... disease -> Decreased ... renal blood flow ... #Pharmacology #Pathophysiology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Pregnancy - Renal ... disease - Bone ... granulamatous disease
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• softening of bones ... Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... neuropathy • Renal ... : - Renal failure
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... Minimal Change Disease ... and decreased renal ... nephrology #Effects #pathophysiology ... #renal
Hypercalcemia - Differential Diagnosis Algorithm
Primary Hyperparathyroidism
 • Adenoma
 • Hyperplasia
 • MEN 1 and 2A
Tertiary Hyperparathyroidism
Renal Failure, Post-Renal ... Cytokine-Mediated Bone ... Lymphomas) Metastatic Bone ... Disease Vitamin ... Granulomatous Disease
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm
Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
Chronic Kidney Disease ... 3 months Pre-Renal ... Atheroemboli • Renal ... hypoperfusion Post-Renal ... Family history, ultrasound