8 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... Massive tumor cell lysis ... ALL, AML, NHL → AKI ... #TLS #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... Precipitation => • Urate ... #TLS #Pathophysiology
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... tetany ↑UA = AKI ... #Syndrome #TLS ... #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... fever - ACS, AKI ... leukapheresis - TLS ... Syndrome: • Pathophysiology ... #Syndrome #TLS
Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
Kidney Injury (AKI ... Urine Na/K/Cl/urea ... uric acid (rhabdo/TLS ... #Nephrology #Diagnosis ... #Algorithm #Causes
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... • Hepatorenal syndromes ... multiple myeloma) • Urate ... #KidneyInjury #Nephrology ... Differential #Diagnosis #Algorithm
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Workup Algorithm ... electrolytes, urea ... • Cardio-renal syndrome ... #Workup #Algorithm ... Differential #Diagnosis #nephrology
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Differential Diagnosis Algorithm ... Osmoles, Increased Urate ... Hyperosmolarity • Cell Lysis ... Tumor Lysis Syndrome ... IntercellularShift #Nephrology