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diagnosis differential algorithm hyponatremia blood hematuria table workup acute atlas casts diuresis diuretics excretion glomerulonephritis hyperkalemia hypotonic injury intercellularshift key
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Kidney Injury - AKI ... osmolarity If cause ... Interstitial nephritis ... Differential #Diagnosis #nephrology ... #causes
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... of Glomerular Bleeding ... Suggestive of glomerular ... #urology #nephrology ... #renal #urine #
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
• Evidence of glomerular ... → Refer to Nephrology ... for renal biopsy ... and referral to Urology ... if cause not identified
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
Atlas of Urine Microscopy ... red - cells Non-glomerular ... also be seen if urine ... brown cast” - Necrotic ... key #diagnosis #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
GI losses • Renal ... Cirrhosis • Nephrotic ... • Reduced GFR, AKI ... Hypo-osmolar urine ... #Hyponatremia #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
GI losses • Renal ... Cirrhosis • Nephrotic ... • Reduced GFR, AKI ... Hypo-osmolar urine ... #Hyponatremia #Nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... formation along glomerular ... glomerulopathy, radiation nephritis ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
time you have a case ... volume-based algorithm Urine ... Losses (AKI, Post-AKI ... failure, Cirrhosis, Nephrotic ... table #sodium #nephrology
Causes of Hyperkalemia - Reduced Excretion - Differential Diagnosis Algorithm Reduced flow through distal nephron - TTKG
nephron - TTKG > 7, Urine ... hypotension) Decreased Glomerular ... Creatinine • Chronic renal ... failure • AKI ... IntercellularShift #Nephrology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
• Metabolic alkalosis ... hyperreactivity • Urologic ... kidney disease, and nephrotic ... Kidney stones caused ... Excretion #Diuresis #Nephrology
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