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hematology algorithm causes hemolysis thrombocytosis atlas cll extravascular intravascular leukemia lymphocytic morphology pulmonary syndromes workup abscess agglutinin anemias antibody aplastic
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... : • Autoimmune ... • Extrinsic RBC ... • Intrinsic RBC ... #Anemias #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Decreased WBCs ... RA, SLE, PRV, Chronic ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Causes #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... ↑ LDH • Anti-RBC ... #Hemolytic #Anemia ... #diagnosis #management ... #treatment #rheumatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... hemolytic anemia ... hemolytic anemia ... #Morphology #differential ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... Membrane): - Autoimmune ... 3) Internal (RBC ... Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... hemolytic anemia ... , Intrinsic RBC ... #anemia #differential ... #diagnosis #calculation
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... elliptocytosis - RBC ... anemia • ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... elliptocytosis, autoimmune ... #Anemia #Differential
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... coagulopathy (DIC) #RBC ... Morphology #Atlas #key #diagnosis ... #differential # ... hematology
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