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diagnosis hematology algorithm causes management microscopy path bloodsmear oncology peripheral intravascular pathophysiology pulmonary rheumatology treatment dermatology hemolysis hepatology laboratory liver
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Abnormal peripheral smear ... • Extrinsic RBC ... • Intrinsic RBC ... #Anemias #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Bleed • Hemolysis ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Differential #
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... AIHA • Anemia ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Decreased RBC ... Infiltration Increased RBC ... Thalassemia • RBC ... Disorder • RBC
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... RBC) Morphology ... Microcytic RBC: ... disease, McLeod blood ... #Morphology #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... 3) Internal (RBC ... - Peripheral Blood ... Smear ↑ abnormal
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... • Peripheral blood ... smear + DAT + further ... Hypochromic & microcytic RBCs ... #Anemia #Differential
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... loss • Hemolytic ... Dilutional Effect • RBC
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Algorithm Normal Blood ... Smear • Drugs ... Neutrophils - Low RBC ... RBCs in Rouleaux
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Anemia #Differential ... Diagnosis #Algorithm #workup
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