55 results
Drug-Induced Thrombocytopenia
The diagnosis of drug-induced thrombocytopenia can be made only by demonstrating resolution of thrombocytopenia once
Drug-Induced Thrombocytopenia ... #Diagnosis #Hematology ... #Thrombocytopenia ... #DrugInduced #Medications ... #Causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... family history - Medications ... test, ANA (e.g., SLE ... or if a primary hematologic ... #Workup #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
: - Thrombocytopenia ... Kasabach-Merritt syndrome ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology #
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Autoimmune: SLE ... antiphospholipid syndrome ... Medicine @SCVMCMed #Thrombocytopenia ... Diagnosis #Framework #hematology
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... 200ng/mL Best indications ... #Measurement #SLE ... #rheumatology # ... levels #lupus #management
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... TTP/HUS, HELLP Syndrome ... Pregnancy (AFLP) Three syndromes ... child * Severe cases ... AFLP #obstetrics #hematology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
block • Sjogren syndrome ... polymyositis overlap syndrome ... • Specific for SLE ... Summary #diagnosis #rheumatology ... #management
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... Pregnancy Three syndromes ... child * Severe cases ... @Bloodman #Thrombocytopenia ... Obstetrics #OBGyn #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Systemic Lupus (SLE ... Demyelinating syndromes ... Leucopenia/lymphopenia, Thrombocytopenia ... #Lupus #SLE #systemic ... symptoms #diagnosis #rheumatology