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diagnosis differential causes sle hemolytic intravascular symptoms systemic anemias autoantibodies criteria deficiency dermatology enlarged ferritin iron mimickers pancytopenia papulosquamous skinrash
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... #Hemolytic #Intravascular ... differential #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... Extravascular ... anemia • ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Differential Diagnosis Algorithm ... Signs of anemia ... #Diagnosis #Algorithm ... #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Diseases: • Systemic lupus ... erythematosus ... Antibody-mediated hemolysis ... Differential #Diagnosis #Hematology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
Erythematosus Clinical ... NEUROLOGIC - HEMOLYTIC ... ANEMIA - LEUKOPENIA ... #Rheumatology # ... SLE #Lupus #Erythematosus
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency Anemia ... Differential Diagnosis Algorithm ... (not extravascular ... ) hemolysis, Intensive ... #ferritin #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... autoantibodies #signs ... #differential #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Differential Diagnosis Algorithm ... Inflammatory • Systemic Lupus ... Erythematosus ... Serum Sickness Hemolytic ... #Causes #Hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... ) Blood (75%): Anemia ... SLE #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Erythrematous ... Auspitz sign, Koebner's ... flat-topped) papules on wrists ... soles • Discoid Lupus ... Erythematous -
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