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diagnosis differential causes workup classification disease macrocytic mcv thrombocytosis aafp approach atlas bloodcell calculation cirrhosis deficiency ferritin folate folicacid gluten
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
< 2: • Anemia ... deficiencies: Iron ... loss), Vitamin B12 ... anemia, Intrinsic ... #hematology #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
to Anemia - Differential ... inflammation) • Iron ... Sideroblastic anemia ... ACD, Aplastic anemia ... MatthewHoMD #Anemia
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... extravascular) hemolysis ... - Structural: Celiac ... #Deficiency #Anemia ... #ferritin #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Bleed • Hemolysis ... • Early Iron ... #Normocytic #Anemia ... #Causes #Hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Anemia - Underproduction ... - Iron deficiency ... anemia - Anemia ... disease - Vitamin B12 ... #hematology #diagnosis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (<80 fL) • Iron ... Poisoning • Anemia ... Marrow Failure • Anemia ... (>100 fL) • B12
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... or B12 repletion ... OR reticulocyte index ... for degree of anemia ... thecurbsiders podcast #Anemia
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Causes of Anemia ... PRODUCTION • Vitamin B12 ... Alcohol related, Iron ... syndrome, Spur cell anemia ... anemia, Hemolysis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
deficiency anemia ... Chronic disease anemia ... Sideroblastic anemia ... Macrocytic RBC: Vitamin B12 ... differential #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... disorders • Celiac ... malignancy • Iron ... deficiency anemia ... Differential #Diagnosis #Algorithm
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