57 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... and Management ... • Immunologic Workup ... : Chronic disease ... #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Antinuclear (ANA ... Treatment: • ... #Summary #diagnosis ... #rheumatology # ... management
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
telomeropathy Cancer ... Inflammatory and ... : • Systemic lupus ... consumption • Vitamin B12 ... #Hematology
Hyperthyroidism (low TSH, High T4/T3) - Diagnostic Algorithm

Radioactive iodine scan – get if concern for nodular
scan – get if concern ... workup choices ... AND management options ... (see below)! ... #Algorithm #Workup
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... hemopathies, solid cancers ... • Systemic diseases ... #diagnosis #management ... #treatment #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months to years) Systemic ... : Chronic disease ... comparison #table #rheumatology ... #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Erythematosus (SLE ... Cerebrovascular Disease ... CNS #neurology #rheumatology ... #management #treatment
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... Arthritis (RA), Systemic ... erythematosus (SLE ... Other Causes: Cancer ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... - Neurological 12% ... Auto-Antibodies: - ANA ... #Systemic #Lupus ... #differential #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
for workup, including ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease