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sle erythematosus syndrome systemic druginduced summary symptoms autoantibodies differential hemeonc hemophagocytic hlh lymphohistiocytosis oncology table thrombocytopenia activation aih anemia anticoagulant
Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid antibodies (aPL ... ): • Lupus anticoagulant ... to be present Treatment ... target to 3-4 • DOACs ... #diagnosis #management
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... , others (RNP, aPL ... Autoantibodies #Rheumatology ... #diagnosis #associations
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... Anti-cardiolipin (aPL ... - Anti-B2GP1 (aPL ... autoantibodies #signs ... #differential #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
permeability Diagnosis ... (for secondary APS ... CNS #neurology #rheumatology ... #cerebritis #diagnosis ... #management #treatment
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... and transfusion as ... anticoagulant #hematology ... #management #pharmacology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... and Management ... life-threatening • Treatment ... Erythematosus #Diagnosis ... #rheumatology
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... severity (ISN/RPS ... #treatment #management ... #rheumatology #
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: - Neuro: AMS ... have fever - ACS ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... life-threatening • Treatment ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology # ... management
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