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differential causes algorithm hypercalcemia management signs symptoms nephrology pseudogout chondrocalcinosis lowcalcium rheumatology alkaline alp bulimianervosa comparison complications constipation cushings deposition
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
failure, Addison's disease ... )-alkali syndrome ... #differential #diagnosis ... #calcium #high ... #endocrinology
Hypocalcemia Laboratory Evaluation Serum levels of PTH, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D can help differentiate between
Hypocalcemia Laboratory ... Hypoparathyroidism - Calcium-sensing ... Chronic kidney disease ... Hyperparathyroidism #Diagnosis ... #Endocrinology
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 Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
Hypocalcemia - Diagnosis ... Activation: Liver disease ... , Kidney Disease ... - Calcium Sequestration ... #endocrinology
Hypocalcemia - Differential Diagnosis Algorithm - Low and High Phosphate LOW PHOSPHATE - Low/NormaI PTH
Hypocalcemia - Differential ... Diagnosis Algorithm ... Phenytoin, Nephrotic Syndrome ... Hepatobiliary Disease ... Algorithm #Phosphate #endocrinology
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Differential Diagnosis ... Granulomatous Disease ... Bony Mets - Calcium ... #Differential #Diagnosis ... Algorithm #causes #endocrinology
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... hypocalciuric hypercalcemia ... #Hypercalcemia ... #Differential #Diagnosis ... #Endocrinology
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 Hypercalcemia - Differential Diagnosis Algorithm Primary Hyperparathyroidism • Adenoma • Hyperplasia • MEN 1 and 2A Tertiary Hyperparathyroidism
Differential Diagnosis ... Autosomal Dominant Calcium ... Other • Excess Calcium ... #Differential #Diagnosis ... #Algorithm #Endocrinology
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Lithium use • Calcium-sensing ... Chronic kidney disease ... • Milk-alkali syndrome ... #Causes #endocrinology ... #diagnosis #differential
Hypocalcemia - Differential Diagnosis Algorithm - Low and High PTH LOW PTH - Hypoparathyroid - Congenital (Pediatric)
Hypocalcemia - Differential ... Diagnosis Algorithm ... • Infiltrative disease ... Tumor lysis syndrome ... Algorithm #PTH #endocrinology
Causes of Hypercalcemia due to increased Vitamin D levels • The BIG 3:
Causes of Hypercalcemia ... granulomatous diseases ... Genetic: Williams syndrome ... #differential #diagnosis ... #endocrinology
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