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differential management dermatology generalized lymphadenopathy aplastic chronic cll diffuse lad lymphocytic mds myelodysplastic pruritus secondary syndrome systemic treatment workup classification
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... - Differential Diagnosis ... • Neoplastic (Leukemia ... #Algorithm #Causes ... #Hematology #Oncology
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
Fever of Unknown ... ’ algorithm • ... thin smear • Signs ... values supporting hematologic ... UnknownOrigin #workup #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Algorithm Spurious ... Chronic Myelogenous Leukemia ... Iron deficiency anemia ... #Algorithm #Causes
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Algorithm Reactive ... #Algorithm #Causes ... #Hematology #Oncology
Differential Diagnosis for Generalized Lymphadenopathy Viral • HIV • EBV • CMV • HBV • Dengue • Rubella
Differential Diagnosis ... Syphilis • Lyme • Leptospirosis ... • Lymphoma • Leukemia ... #Causes #Algorithm ... #Oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Diagnosis: • Pancytopenia ... if neutropenic fever ... to MDS or acute leukemia ... #treatment #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... #Algorithm #Causes ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... Management #treatment #hematology ... #oncology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
- Differential Diagnosis ... Algorithm Hereditary ... HTN) • Recent travel ... /Fevers, DAT (-) ... #Algorithm #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... Headaches, bone pain, fever ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
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