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differential workup causes management oncology thrombocytosis anemia classification coagulation dic disseminated emergencies hemeonc hemolytic hodgkins hypercoagulable intravascular leukocytosis lymphoma oncologic
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
of hematologic ... malignancy: • ... anemia, ↑ MCV, ↑/↓ platelets ... #Algorithm #hematology ... #WBC #Leukemoid
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Algorithm Spurious ... Artifact (redo CBC ... Chronic Myelogenous Leukemia ... malignancy •
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Algorithm • 12 ... -13 g/dL, • ANC ... < 1800/uL, • platelet ... : CBC with diff, ... #Algorithm #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Algorithm Peripheral ... concerning for malignancy ... for workup, including ... #Algorithm #hematology
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
trauma, active malignancy ... - No other workup ... cancer screening, CBC ... #hematology #diagnosis ... #algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... with or without platelet ... valve, vasculitis, malignant ... #Algorithm #workup ... #hematology #testing
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
trauma, sepsis, malignancy ... promyelocytic leukemia ... hydration • RBC ... #Coagulation #diagnosis ... treatment #management #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hematological malignancy ... Hodgkin Lymphoma Workup ... - Low Hb and platelets ... - WBC may be ... classification #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... syndrome): - Hematologic ... sticky” cells; WBC ... Hypercalcemia of malignancy ... Oncology #HemeOnc #Diagnosis
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