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rheumatology causes algorithm treatment anemia classification dermatology druginduced medications syndrome erythematosus hemolytic hepatology sle systemic table alopecia deficiency hairloss hyperkalemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... infection) - Drugs ... Extravascular #Causes #differential ... #diagnosis #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... atypical HUS) - Drug-induced ... #schistocytes #differential ... #diagnosis #hematology ... #hemolysis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... delayed HTR • Drug-induced ... #Diagnosis #Algorithm ... #Causes #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... • Blood smear: Differential ... #Anemia #diagnosis ... #management #treatment ... #rheumatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Membrane Defects, Drugs ... #Differential # ... Diagnosis #hematology
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... in Hemolytic Anemia ... #medications #Hemolytic ... #Anemia #differential ... #diagnosis #pharmacology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diagnosis Congenital ... Diseases: • Systemic lupus ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Lymphadenopathies 7% - Hemolytic ... (aPL) 30-45% Differential ... Diagnosis and Lupus ... Mimickers: Drug-induced ... #rheumatology
Medications associated with drug-induced lupus List of Definite and Possible Associated Drugs #Diagnosis #Pharmacology #Medications #DrugInduced #Lupus #List
lupus List of ... #Diagnosis #Pharmacology ... #DrugInduced #Lupus ... #List #Causes #Differential ... #Drugs
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Splenomegaly - Differential ... Diagnosis Algorithm ... Inflammatory • Systemic Lupus ... Serum Sickness Hemolytic ... #Causes #Hematology
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