51 results
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
activity, ↑ soluble IL ... the following 8 criteria ... activity • ↑ soluble IL ... Lymphohistiocytosis #diagnosis #hematology ... #criteria
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Classification Criteria ... pericarditis • Hematologic ... nephritis, Class Ill ... Classification #Criteria ... Erythematosus #diagnosis #rheumatology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
to be normal. 1: ... 1 Mix of Patient's ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... transfusion • Criteria ... : ARDS Berlin Criteria ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Myositis: Anti-JO-1, ... RNA Polymerase Ill ... Autoantibodies #Rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... (MDS) Most met criteria ... for 1) hematologic ... Autoinflammatory #Somatic #rheumatology
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
Diagnosis of HUV 1) ... anti-IgE, anti-IL ... -1 Dr. ... Diagnosis #Management #Rheumatology
4T Score for Heparin-Induced Thrombocytopenia

Interpretation of the 4T score:
0-3 points:  Low probability (<<1%)
  -
probability (<<1% ... Thrombocytopenia #Diagnosis #Criteria ... #Hematology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
5 of the below criteria ... should be major: 1. ... Minor criteria include ... Treatment - Mild ... AOSD #diagnosis #rheumatology
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Vasculitis 1) ... (types II and Ill ... Vasculitis #Diagnosis #Rheumatology