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diagnosis management differential syndrome treatment comparison dermatology hemophagocytic hlh table disease lupus thrombocytopenia behavioraldisorder oncology psychiatry signs sle symptoms vasculitis
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Hemophagocytic Lymphohistiocytosis ... activity, ↑ soluble IL ... activity • ↑ soluble IL ... Hemophagocytic #Lymphohistiocytosis ... #diagnosis #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
haemophagocytic lymphohistiocytosis ... -1 and IL-6, leading ... Histopathologic criteria ... Diagnosis #Management #Hematology ... #Rheumatology
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Disease - Yamaguchi Criteria ... Major criteria ... 39C lasting >= 1 ... >= 80% Minor criteria ... #Major #Minor #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009 At least three of the following: -
Hemophagocytic Lymphohistiocytosis ... HLH) Diagnostic Criteria ... CD25 (soluble IL2 ... #Diagnosis #Criteria ... #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... (HLH) Pathophysiology ... cytokines (TNFa,lL1, IL6 ... Hemophagocytic #Lymphohistiocytosis ... treatment #summary #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... pericarditis • Hematologic ... nephritis, Class Ill ... Classification #Criteria ... Erythematosus #diagnosis #rheumatology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
to be normal. 1: ... 1 Mix of Patient's ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
blood donor • Pathophysiology ... transfusion • Criteria ... : ARDS Berlin Criteria ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Myositis: Anti-JO-1, ... RNA Polymerase Ill ... Autoantibodies #Rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... (MDS) Most met criteria ... for 1) hematologic ... Autoinflammatory #Somatic #rheumatology
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