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diagnosis hematology differential table comparison management syndrome aflp antinuclear cytoplasmic dermatomyositis gammopathy hellp mgus monoclonal obstetrics pregnancy testing thrombocytopenia ttphus
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... ARUPConsult @ARUPLabs #ANA ... differential #diagnosis #rheumatology
Nodular pattern 1. Hypersensitivity pneumonitis: ill defined centrilobular nodules. 2. Miliary TB: random nodules 3. Sarcoidosis: nodules with perilymphatic
Nodular pattern ... 1. ... Hypersensitivity pneumonitis ... : ill defined centrilobular ... next to pleura and
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... (anti-nuclear antibody ... Antiphospholipid Antibody ... Myositis: Anti-JO-1, ... Polymerase Ill
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
activity (e.g. antibody ... to be normal. 1: ... 1 Mix of Patient's ... Study #diagnosis #hematology ... pathophysiology #hematology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon • EJ, Jo-1, ... ARUPConsult @ARUPLabs #ANA ... differential #diagnosis #rheumatology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
similar aggregation pattern ... cytometry — GP Ilb ... agonists • This pattern ... either severe Type 1 ... Platelet #disorders #hematology
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Microangiopathy - TMAs 1. ... drug-associated TMA (antibody ... vs toxicity, and ... metabolism and ... Microangiopathy #TMAs #hematology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Thrombocytopenia and ... the critically ill ... coagulation defects. 1) ... coagulation defects and ... Obstetrics #OBGyn #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Thrombocytopenia and ... HELLP Syndrome and ... the critically ill ... coagulation defects. 1) ... AFLP #obstetrics #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
ILD worsens ... prevalence of RP-ILD ... Phenotype 1 ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
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