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Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Reticulocyte count ... in peripheral blood ... High in acute blood ... Corrected reticulocyte ... count OR reticulocyte
Polychromatophilia - Note 2 large blue-gray erythrocytes as seen on H&E stain. On a stain for
On a stain for reticulocytes ... The reticulocyte ... nucleated red blood ... Path #BloodSmear #Blood
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Reticulocyte Production ... days) it takes a reticulocyte ... the peripheral blood ... including chronic blood ... > 3: • Acute blood
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... of: Decreased Reticulocytes ... Normal / Decreased Reticulocytes ... Destruction - Increased Reticulocytes
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
(RBC = red blood ... peripheral smear, a reticulocyte ... specifically order a reticulocyte ... likely cause if the reticulocyte ... elevation in the reticulocyte
Plasmodium Falciparum Blood Smear.
Key features suggesting Plasmodium falciparum:
- extreme parasitemia
- normocytic RBCs (vivax, ovale prefer big
Plasmodium Falciparum Blood ... ovale prefer big reticulocytes ... P.f. but rare in blood ... Plasmodium #Falciparum #Blood
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
proportion of the red blood ... i.e., corrected reticulocyte ... i.e., corrected reticulocyte ... three peripheral blood ... #Pancytopenia #reticulocytes
Nucleated red blood cells, aka normoblasts or erythroblasts, were released prematurely from the bone marrow in
Nucleated red blood ... orthochromic normoblast – reticulocyte ... #BloodSmear #Blood
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
normocytic, ↑ reticulocytes ... type ± C3d • Blood
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Peripheral Blood ... abnormal RBCs - Reticulocyte