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differential management anemia algorithm arthritis hemolysis workup causes intravascular joint pain rbc table treatment aiha approach atlas classification coagulation comparison
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... : • Autoimmune ... • Extrinsic RBC ... #Differential #Diagnosis ... #Algorithm #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... idiopathic) - Autoimmune ... • Intrinsic RBC ... #differential #diagnosis ... #hematology #anemia
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... ↑ LDH • Anti-RBC ... #diagnosis #management ... #treatment #rheumatology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... #Hemolytic #Anemia ... #Pathophysiology ... #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... - Differential Diagnosis ... Cold Agglutinin Disease ... #Hemolytic #Anemia ... #Table #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... elliptocytosis, autoimmune ... #Differential #Diagnosis ... Algorithm #workup #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
spherocytosis, Autoimmune ... hemolytic anemia ... Agglutinate: Cold autoimmune ... #differential #diagnosis ... #hematology #microscopy
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... Cold AIHA • Alloimmune ... elliptocytosis - RBC ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
DAT Results in Autoimmune ... Cold agglutinin disease ... antiglobulin #test #DAT #Autoimmune ... #Hemolysis #hematology ... #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Membrane): - Autoimmune ... , Drugs, Liver Disease ... #hematology
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