11 results
differential anemia algorithm causes hemolysis extravascular intravascular management rheumatology agglutinin aiha anemias babesia classification cold criteria disease erythematosus eularacr infectiousdiseases
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... C3d • Blood smear ... #Autoimmune #Hemolytic ... #Anemia #diagnosis
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Abnormal peripheral smear ... : • Autoimmune ... #Differential #Diagnosis ... #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
- Differential Diagnosis ... Peripheral blood smear ... idiopathic, malignancy, autoimmune ... Infection mediated (Babesiosis ... #Differential #Diagnosis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... or negative - Smear ... C3 positive - Smear ... Pathophysiology #diagnosis ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... idiopathic) - Autoimmune ... Infections: Malaria, Babesiosis ... #differential #diagnosis ... #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... Cold AIHA • Alloimmune ... Malaria • Babesiosis ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Membrane): - Autoimmune ... toxins: Malaria, Babesiosis ... Peripheral Blood Smear ... #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... Inflammatory and Autoimmune ... hemoglobinuria • Antibody-mediated ... hemolysis Nutritional ... #Hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
pericarditis • Hematologic ... Thrombocytopenia, Autoimmune ... hemolysis • Renal ... Erythematosus #diagnosis ... #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... Diagnosis: • hemolytic ... IgM) • Blood smear ... CLL (older) • Autoimmune ... #anemia #hematology
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