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rheumatology differential antinuclear workup erythematosus lupus patterns testing algorithm anemia antibodies autoantibodies management systemic associations classification criteria cytoplasmic disease diseases
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... C3d • Blood smear ... Pouchelon #Warm #Antibody ... #Anemia #diagnosis
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Signs of anemia and ... Abnormal peripheral smear ... #Differential #Diagnosis ... #Algorithm #hematology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... NEUROLOGIC - HEMOLYTIC ... IMMUNOLOGIC CRITERIA - ANA ... anemia #Diagnosis ... #Rheumatology #
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
microangiopathic hemolytic ... laboratory diagnosis ... arrow) Peripheral smear ... #anemia #Hematology ... #Pathology #Smear
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
SHARP - Lupus Diagnosis ... A Antinuclear Antibody ... (ANA) M Mucositis ... Pleuritis) H Hematologic ... #IMDAMNSHARP #sle
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Disease Associations ANA ... polyangiitis U1-RNP antibody ... disease Endomyseal antibody ... Associations #diseases #diagnosis ... #table #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
pericarditis • Hematologic ... Thrombocytopenia, Autoimmune hemolysis ... low C4, Low C3 and ... Classification #Criteria #SLE ... Erythematosus #diagnosis
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... antibody), dsDNA ... Antiphospholipid Antibody ... #diagnosis #associations
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... Inflammatory and ... hemoglobinuria • Antibody-mediated ... hemolysis Nutritional ... #Hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
- Differential Diagnosis ... 12-13 g/dL, • ANC ... acid, peripheral smear ... ↑ Destruction (hemolysis ... #Algorithm #hematology
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