11 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... : → Massive tumor ... ALL, AML, NHL → AKI ... #TLS #Pathophysiology
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... tetany ↑UA = AKI ... worsens above #Tumor ... #TLS #Pathophysiology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Kidney Injury (AKI ... Interleukin-2) • Tumor ... Kidney #Injury #AKI ... Cancer #Oncology #Differential ... Classification #Nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... ) - Differential ... Abdominal Compartment Syndrome ... • Obstruction (Tumor ... #Diagnosis #nephrology
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
HyperKalemia - Differential ... Rhabdomyolysis • Tumor ... lysis syndrome ... Elimination: • AKI ... blockers - MCW Nephrology
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Hyperphosphatemia - Differential ... Rhabdomyolysis, Tumor ... lysis syndrome, ... Kidney Disease: • AKI ... Workup #phosphate #nephrology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Myelitis, Trauma, Tumor ... Motor Nerves: ALS ... Guillain-Barre syndrome ... Weakness #Causes #differential ... #diagnosis #neurology
Hypophosphatemia - Differential Diagnosis Algorithm
Appropriately Low Kidney Phosphate Excretion:
 • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Hypophosphatemia - Differential ... Respiratory Alkalosis, Tumor ... Hyperparathyroidism, TKI ... Hypophosphatemia #Differential ... Diagnosis #Algorithm #nephrology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Tumor-associated ... Wilson's disease Pulmonary ... - SLE Neurologic ... Lymphadenopathy • Tumor-associated ... #joint #pain #differential