The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Conduct Disorder (CD): Pathogenesis and clinical findings
 - Must have >3 symptoms present in the past
Conduct Disorder (CD ... >18 years old, criteria ... not be met for antisocial ... #signs #psychiatry ... #criteria
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
the etiology Signs ... /Symptoms: - Pretibial ... pathophysiology #endocin #endocrinology ... #symptoms #signs
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
auto-reactive B and CD ... pathophysiology #diagnosis #signs ... #symptoms #complications
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Signs/Symptoms: ... Hyperthyroidism #endocrinology
Antisocial Personality Disorder (ASPD): Pathogenesis and Clinical Findings
Work & lnterpersonal:
 • Home Life Troubles - Conflict
Antisocial Personality ... disorder #ASPD #Antisocial ... Diagnosis #Psychiatry #Criteria ... #Signs #Symptoms
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Clinical Findings Symptoms ... included in DSM 5 criteria ... suicide Other Symptoms ... Pathophysiology #Signs ... #Symptoms #Psychiatry
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Overproduction #diagnosis #signs ... #symptoms #endocrinology
Borderline Personality Disorder: Pathogenesis and Clinical Findings
Behavioral Traits:
 • Unstable Relationships - Alternating extremes of idealization
severe dissociative symptoms ... the above with symptoms ... Diagnosis #Psychiatry #Criteria ... #Signs #Symptoms
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
have either 26 symptoms ... Hyperactivity-Impulsivity or >6 symptoms ... 2 settings - Symptoms ... #signs #psychiatry ... #criteria